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Article

Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7.

The Journal of biological chemistry - 6 Mar 2015

Stadler Theresa, O'Reilly Andrias O, Lampert Angelika

Abstract excerpt

The human voltage-gated sodium channel Nav1.7 plays a crucial role in transmission of noxious stimuli. The inherited pain disorder erythromelalgia (IEM) has been linked to Nav1.7 gain-of-function mutations. Here we show that the IEM-associated Q875E mutation located on the pore module of Nav1.7 produces a large hyperpolarizing shift (-18 mV) in the voltage dependence of activation. Three-dimensional homology...

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Identifiers

PMID: 25575597
DOI: 10.1074/jbc.M114.605899
PMCID: PMC4358268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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