Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.

doi:10.1085/jgp.202313450

Back to search

Article

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.

The Journal of general physiology - 4 Dec 2023

Wisedchaisri Goragot, Gamal El-Din Tamer M, Powell Natasha M, Zheng Ning, Catterall William A

Abstract excerpt

Voltage-gated sodium channels in peripheral nerves conduct nociceptive signals from nerve endings to the spinal cord. Mutations in voltage-gated sodium channel NaV1.7 are responsible for a number of severe inherited pain syndromes, including inherited erythromelalgia (IEM). Here, we describe the...

Topics

Humans
Erythromelalgia
Models, Molecular
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Pain

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.