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Article

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.

The Journal of general physiology - 4 Dec 2023

Wisedchaisri Goragot, Gamal El-Din Tamer M, Powell Natasha M, Zheng Ning, Catterall William A

Abstract excerpt

Voltage-gated sodium channels in peripheral nerves conduct nociceptive signals from nerve endings to the spinal cord. Mutations in voltage-gated sodium channel NaV1.7 are responsible for a number of severe inherited pain syndromes, including inherited erythromelalgia (IEM). Here, we describe the negative shifts in the voltage dependence of activation in the bacterial sodium channel NaVAb as a result of the...

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Identifiers

PMID: 37903281
DOI: 10.1085/jgp.202313450
PMCID: PMC10616507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.PMID 37903281Read ↗

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