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Article

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.

Protein & cell - 1 Jun 2017

Huang Weiyun, Liu Minhao, Yan S Frank, Yan Nieng

Abstract excerpt

Voltage-gated sodium (Nav) channels are essential for the rapid upstroke of action potentials and the propagation of electrical signals in nerves and muscles. Defects of Nav channels are associated with a variety of channelopathies. More than 1000 disease-related mutations have been identified in Nav channels, with Nav1.1 and Nav1.5 each harboring more than 400 mutations. Nav channels represent major targets for...

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Identifiers

PMID: 28150151
DOI: 10.1007/s13238-017-0372-z
PMCID: PMC5445024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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