Article
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel NaV1.7.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2023
Wisedchaisri Goragot, Gamal El-Din Tamer M, Zheng Ning, Catterall William A
Abstract excerpt
Gain-of-function mutations in voltage-gated sodium channel NaV1.7 cause severe inherited pain syndromes, including inherited erythromelalgia (IEM). The structural basis of these disease mutations, however, remains elusive. Here, we focused on three mutations that all substitute threonine residues in the alpha-helical S4-S5 intracellular linker that connects the voltage sensor to the pore: NaV1.7/I234T,...
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