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Article

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021

Pan Xiaojing, Li Zhangqiang, Jin Xueqin, Zhao Yanyu, Huang Gaoxingyu, Huang Xiaoshuang, Shen Zilin, Cao Yong, Dong Mengqiu, Lei Jianlin, Yan Nieng

Abstract excerpt

Among the nine subtypes of human voltage-gated sodium (Nav) channels, the brain and cardiac isoforms, Nav1.1 and Nav1.5, each carry more than 400 missense mutations respectively associated with epilepsy and cardiac disorders. High-resolution structures are required for structure-function relationship dissection of the disease variants. We report the cryo-EM structures of the full-length human Nav1.1-β4 complex at...

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Identifiers

PMID: 33712547
DOI: 10.1073/pnas.2100066118
PMCID: PMC7980448

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Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.PMID 33712547Read ↗

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