Article
Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2024
Xicota Laura, Cosentino Stephanie, Vardarajan Badri, Mayeux Richard, Perls Thomas T, Andersen Stacy L, Zmuda Joseph M, Thyagarajan Bharat, Yashin Anatoli, Wojczynski Mary K, Krinsky-McHale Sharon, Handen Benjamin L, Christian Bradley T, Head Elizabeth, Mapstone Mark E, Schupf Nicole, Lee Joseph H, Barral Sandra
Abstract excerpt
INTRODUCTION: Late-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics. METHODS: We conducted a whole genome sequence analysis of 3475 LLFS members. Genetic associations were examined in six independent studies (N = 14,260) with a wide range of LOAD risk....
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