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Article

Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2015

Barral Sandra, Cheng Rong, Reitz Christiane, Vardarajan Badri, Lee Joseph, Kunkle Brian, Beecham Gary, Cantwell Laura S, Pericak-Vance Margaret A, Farrer Lindsay A, Haines Jonathan L, Goate Alison M, Foroud Tatiana, Boerwinkle Eric, Schellenberg Gerard D, Mayeux Richard

Abstract excerpt

INTRODUCTION: We performed linkage analyses in Caribbean Hispanic families with multiple late-onset Alzheimer's disease (LOAD) cases to identify regions that may contain disease causative variants. METHODS: We selected 67 LOAD families to perform genome-wide linkage scan. Analysis of the linked regions was repeated using the entire sample of 282 families. Validated chromosomal regions were analyzed using joint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26433351
DOI: 10.1016/j.jalz.2015.07.487
PMCID: PMC4690771

Genes

GHRHR
NEUROD6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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