MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses.

doi:10.18632/oncotarget.9819

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MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses.

Oncotarget - 28 Jun 2016

Tang Shan-Shan, Wang Hui-Fu, Zhang Wei, Kong Ling-Li, Zheng Zhan-Jie, Tan Meng-Shan, Tan Chen-Chen, Wang Zi-Xuan, Tan Lin, Jiang Teng, Yu Jin-Tai, Tan Lan

Abstract excerpt

The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene...

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PMID: 27276684
DOI: 10.18632/oncotarget.9819
PMCID: PMC5129919

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APOE
APP

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