Article
Genetic Determinants of Survival in Patientswith Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2015
Wang Xingbin, Lopez Oscar, Sweet Robert A, Becker James T, DeKosky Steven T, Barmada Mahmud M, Feingold Eleanor, Demirci F Yesim, Kamboh M Ilyas
Abstract excerpt
There is a strong genetic basis for late-onset of Alzheimer’s disease (LOAD), and thus far >20 genes/loci have been identified that affect the risk of LOAD. In addition to disease risk, genetic variation at these loci may also affect components of the natural history of AD, such as survival in AD. In this study, we first examined the role of known LOAD genes with survival time in 983 AD patients. We then...
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