Article
Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2016
Kunkle Brian W, Jaworski James, Barral Sandra, Vardarajan Badri, Beecham Gary W, Martin Eden R, Cantwell Laura S, Partch Amanda, Bird Thomas D, Raskind Wendy H, DeStefano Anita L, Carney Regina M, Cuccaro Michael, Vance Jeffrey M, Farrer Lindsay A, Goate Alison M, Foroud Tatiana, Mayeux Richard P, Schellenberg Gerard D, Haines Jonathan L, Pericak-Vance Margaret A
Abstract excerpt
INTRODUCTION: Few high penetrance variants that explain risk in late-onset Alzheimer's disease (LOAD) families have been found. METHODS: We performed genome-wide linkage and identity-by-descent (IBD) analyses on 41 non-Hispanic white families exhibiting likely dominant inheritance of LOAD, and having no mutations at known familial Alzheimer's disease (AD) loci, and a low burden of APOE ε4 alleles. RESULTS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.