Article
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
PLoS genetics - 23 Sept 2010
Naj Adam C, Beecham Gary W, Martin Eden R, Gallins Paul J, Powell Eric H, Konidari Ioanna, Whitehead Patrice L, Cai Guiqing, Haroutunian Vahram, Scott William K, Vance Jeffery M, Slifer Michael A, Gwirtsman Harry E, Gilbert John R, Haines Jonathan L, Buxbaum Joseph D, Pericak-Vance Margaret A
Abstract excerpt
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492...
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