Article
The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Gerrish Amy, Russo Giancarlo, Richards Alexander, Moskvina Valentina, Ivanov Dobril, Harold Denise, Sims Rebecca, Abraham Richard, Hollingworth Paul, Chapman Jade, Hamshere Marian, Pahwa Jaspreet Singh, Dowzell Kimberley, Williams Amy, Jones Nicola, Thomas Charlene, Stretton Alexandra, Morgan Angharad R, Lovestone Simon, Powell John, Proitsi Petroula, Lupton Michelle K, Brayne Carol, Rubinsztein David C, Gill Michael, Lawlor Brian, Lynch Aoibhinn, Morgan Kevin, Brown Kristelle S, Passmore Peter A, Craig David, McGuinness Bernadette, Todd Stephen, Johnston Janet A, Holmes Clive, Mann David, Smith A David, Love Seth, Kehoe Patrick G, Hardy John, Mead Simon, Fox Nick, Rossor Martin, Collinge John, Maier Wolfgang, Jessen Frank, Kölsch Heike, Heun Reinhard, Schürmann Britta, van den Bussche Hendrik, Heuser Isabella, Kornhuber Johannes, Wiltfang Jens, Dichgans Martin, Frölich Lutz, Hampel Harald, Hüll Michael, Rujescu Dan, Goate Alison M, Kauwe John S K, Cruchaga Carlos, Nowotny Petra, Morris John C, Mayo Kevin, Livingston Gill, Bass Nicholas J, Gurling Hugh, McQuillin Andrew, Gwilliam Rhian, Deloukas Panagiotis, Davies Gail, Harris Sarah E, Starr John M, Deary Ian J, Al-Chalabi Ammar, Shaw Christopher E, Tsolaki Magda, Singleton Andrew B, Guerreiro Rita, Mühleisen Thomas W, Nöthen Markus M, Moebus Susanne, Jöckel Karl-Heinz, Klopp Norman, Wichmann H-Erich, Carrasquillo Minerva M, Pankratz V Shane, Younkin Steven G, Jones Lesley, Holmans Peter A, O'Donovan Michael C, Owen Michael J, Williams Julie
Abstract excerpt
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether common genetic variation in these genes confer risk to the common form of AD which occurs later in life (>65 years). We therefore tested single-nucleotide polymorphisms at these loci for...
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