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Article

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

1 Jul 2014

Abstract excerpt

INTRODUCTION: MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer's disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although insufficient power and incomplete assessment of MAPT haplotypes may account for this. METHODS: We examined the association of MAPT haplotypes with LOAD risk in...

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PMID: 25324900
DOI: 10.1186/alzrt268

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