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Article

Time-integrated BMP signaling determines fate in a stem cell model for early human development

17 Feb 2024

Abstract excerpt

How paracrine signals are interpreted to yield multiple cell fate decisions in a dynamic context during human development in vivo and in vitro remains poorly understood. Here we report an automated tracking method to follow signaling histories linked to cell fate in large numbers of human pluripotent stem cells (hPSCs). Using an unbiased statistical approach, we discover that measured BMP signaling history...

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PMID: 38368368
DOI: 10.1038/s41467-024-45719-9

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