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Article

Phenotype-based identification of mouse chromosome instability mutants.

Genetics - 1 Mar 2003

Shima Naoko, Hartford Suzanne A, Duffy Ted, Wilson Lawriston A, Schimenti Kerry J, Schimenti John C

Abstract excerpt

There is increasing evidence that defects in DNA double-strand-break (DSB) repair can cause chromosome instability, which may result in cancer. To identify novel DSB repair genes in mice, we performed a phenotype-driven mutagenesis screen for chromosome instability mutants using a flow cytometric peripheral blood micronucleus assay. Micronucleus levels were used as a quantitative indicator of chromosome damage in...

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Identifiers

PMID: 12663541
DOI: 10.1093/genetics/163.3.1031
PMCID: PMC1462482

Genes

POLQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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