Article
Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies.
DNA repair - 1 Aug 2025
Marodin Rafaela Horbach, Cozma Ecaterina, Reytan-Miron Sivan, O'Neil Nigel J, Stirling Peter C, Hieter Philip
Abstract excerpt
Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chromatin (SMC) activity. These effects are manifested through its major function in sister chromatid cohesion, but also through activities during DNA replication, repair, and transcription. The array of cohesin functions can make interpreting cellular effects of cohesin loss difficult to...
Topics
- Cohesins
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Saccharomyces cerevisiae
- DNA Damage
- Mutation
- DNA Replication
- Saccharomyces cerevisiae Proteins
- Homologous Recombination
- DNA Repair