Article
Mutated tumor alleles are expressed according to their DNA frequency.
Scientific reports - 22 Apr 2014
Castle John C, Loewer Martin, Boegel Sebastian, Tadmor Arbel D, Boisguerin Valesca, de Graaf Jos, Paret Claudia, Diken Mustafa, Kreiter Sebastian, Türeci Özlem, Sahin Ugur
Abstract excerpt
The transcription of tumor mutations from DNA into RNA has implications for biology, epigenetics and clinical practice. It is not clear if mutations are in general transcribed and, if so, at what proportion to the wild-type allele. Here, we examined the correlation between DNA mutation allele frequency and RNA mutation allele frequency. We sequenced the exome and transcriptome of tumor cell lines with large copy...
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