RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer.

Abstract excerpt

RNA splicing is a critical process governing gene expression and transcriptomic diversity. Despite its importance, a detailed examination of transcript variation at the splicing junction level remains scarce. Here, we perform a thorough analysis of RNA splicing junctions in 34,775 samples across multiple sample types. We identified 29,051 tumor-specific transcripts (TSTs) in pan-cancer, with a majority of these...

Topics

Join the communities discussing this publication.

• Gene Expression Regulation, Neoplastic
• Mutation
• Neoplasms
• RNA, Messenger
• RNA Splicing