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Article

Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts.

Journal of cellular and molecular medicine - 1 Feb 2024

Yang Luzi, Liu Zhanzhao, Sun Jinhuan, Chen Zhan, Gao Fei, Guo Yuxuan

Abstract excerpt

Base editors are emerging as powerful tools to correct single-nucleotide variants and treat genetic diseases. In particular, the adenine base editors (ABEs) exhibit robust and accurate adenine-to-guanidine editing capacity and have entered the clinical stage for cardiovascular therapy. Despite the tremendous progress using ABEs to treat heart diseases, a standard technical route toward successful ABE-based...

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Identifiers

PMID: 38332517
DOI: 10.1111/jcmm.18145
PMCID: PMC10853587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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