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Article

Therapeutic base editing alleviates restrictive cardiomyopathy.

Cell reports. Medicine - 17 Mar 2026

Chang Chong, Zhang Xiulin, Fan Xiaoqi, Chang Yuan, Feng Yihang, Li Geng, Jia Hao, Wen Shuang, Zhang Ningning, Hua Xiumeng, Cui Hao, Chen Xiao, Song Jiangping, Chang Xing

Abstract excerpt

Restrictive cardiomyopathy (RCM) is a severe cardiac disorder characterized by impaired ventricular filling and diastolic dysfunction, with mutations in sarcomeric proteins representing major causative factors. Mutations of TNNI3 gene (e.g., p.R192H) constitute major genetic causes of RCM, particularly affecting pediatric patients and being associated with poor prognosis. Here, we demonstrate that adenine base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41763217
DOI: 10.1016/j.xcrm.2026.102639
PMCID: PMC13006422

Genes

TNNI3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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