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Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer

8 Feb 2024

Abstract excerpt

Neutrophil (PMN) tissue accumulation is an established feature of ulcerative colitis (UC) lesions and colorectal cancer (CRC). To assess the PMN phenotypic and functional diversification during the transition from inflammatory ulceration to CRC we analyzed the transcriptomic landscape of blood and tissue PMNs. Transcriptional programs effectively separated PMNs based on their proximity to peripheral blood,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38329810
DOI: 10.1172/jci174545

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