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Article

Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis

17 May 2023

Abstract excerpt

Abstract Microglia play a role in the pathogenesis of many retinal diseases. Fundus spots in mice often correlate with the accumulation of activated subretinal microglia. Here we use a semiquantitative fundus spot scoring scale in combination with an unbiased, state-of-the-science forward genetics pipeline to identify causative associations between chemically induced mutations and fundus spot phenotypes. Among...

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PMID: 37198396
DOI: 10.1038/s42003-023-04870-7

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