Article

Disease-associated microglia and activation of CD8 <sup>+</sup> T cells precede neuronal cell loss in a model of hereditary spastic paraplegia

2024-09-03

Abstract excerpt

In central nervous system (CNS) diseases characterized by late-onset neurodegeneration, the interplay between innate and adaptive immune responses remains poorly understood. This knowledge gap is amplified by the prolonged nature of these diseases, complicating the delineation of brain-resident and infiltrating cells. Here, we conducted a comprehensive profiling of innate and adaptive immune cells across various C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7641b2f4-77f5-584e-ba5b-fe24820840f0
DOI: 10.1101/2024.09.02.610538

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease-associated microglia and activation of CD8 <sup>+</sup> T cells precede neuronal cell loss in a model of hereditary spastic paraplegiaDOI 10.1101/2024.09.02.610538Read

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.Semantic proximity Read

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity Read

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainSemantic proximity Read

CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System AtrophySemantic proximity Read

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive DiseaseSemantic proximity Read

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read

Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injurySemantic proximity Read

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Semantic proximity Read

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencingSemantic proximity Read

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.Semantic proximity Read

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse modelSemantic proximity Read

CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators.Semantic proximity Read