Article
Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification.
Genome medicine - 5 Feb 2024
Wang Xinan, Zhang Ziwei, Ding Yi, Chen Tony, Mucci Lorelei, Albanes Demetrios, Landi Maria Teresa, Caporaso Neil E, Lam Stephen, Tardon Adonina, Chen Chu, Bojesen Stig E, Johansson Mattias, Risch Angela, Bickeböller Heike, Wichmann H-Erich, Rennert Gadi, Arnold Susanne, Brennan Paul, McKay James D, Field John K, Shete Sanjay S, Le Marchand Loic, Liu Geoffrey, Andrew Angeline S, Kiemeney Lambertus A, Zienolddiny-Narui Shan, Behndig Annelie, Johansson Mikael, Cox Angie, Lazarus Philip, Schabath Matthew B, Aldrich Melinda C, Hung Rayjean J, Amos Christopher I, Lin Xihong, Christiani David C
Abstract excerpt
BACKGROUND: Although polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS), the individual-level accuracy of lung cancer PRS and the extent to which its impact on subsequent clinical applications remains largely unexplored. METHODS: Lung cancer PRSs and confidence/credible interval (CI) were constructed using two statistical approaches...
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