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Validation of lung cancer polygenic risk scores in a high-risk case-control cohort.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2023

Lebrett Mikey B, Smith Miriam J, Crosbie Emma J, Bowes John, Byers Helen J, Evans D Gareth, Crosbie Philip A J

Abstract excerpt

PURPOSE: Screening with low-dose computed tomography reduces lung cancer (LC) mortality. Risk prediction models used for screening selection do not include genetic variables. Here, we investigated the performance of previously published polygenic risk scores (PRSs) for LC, considering their potential to improve screening selection. METHODS: We validated 9 PRSs in a high-risk case-control cohort, comprising...

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PMID: 37154150
DOI: 10.1016/j.gim.2023.100882

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