Article

Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for Tauopathies

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Tauopathies, including Alzheimer’s disease, are neurodegenerative disorders characterized by the accumulation of microtubule-associated protein tau, which is closely linked to cognitive decline. Reduction of tau is a potential and promising strategy for addressing tau-linked brain disorders. We report the development of a therapeutic approach using adeno-associated virus mediated delivery of an...

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Literature Corpus work: 765d83fd-373d-54e5-8e00-8745ed24bcb7
DOI: 10.1101/2025.10.12.681935

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