Article

Evaluating the efficacy of commercially available antisense oligonucleotides to reduce mouse and human tau <i>in vivo</i>

2022-12-29

Abstract excerpt

Tauopathies, including Alzheimer’s disease (AD), are neurodegenerative diseases characterized by the accumulation of tau protein encoded by the MAPT (Microtubule Associated Protein Tau) gene. Various strategies targeting mechanisms to reduce tau pathology have been proposed and several tau-directed therapies are being investigated in clinical trials. Our lab previously developed a novel strategy to lower tau prot...

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Literature Corpus work: 2ab6ccbb-5b66-5cc3-b85c-0573facd0261
DOI: 10.1101/2022.12.29.522258

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