Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau Silencing by siRNA in the P301S Mouse Model of Tauopathy

26 Sept 2014

Abstract excerpt

Suppression of tau protein expression has been shown to improve behavioral deficits in mouse models of tauopathies, offering an attractive therapeutic approach. Experimentally this had been achieved by switching off the promoters controlling the transgenic human tau gene (MAPT), which is not possible in human patients. The aim of the present study was therefore to evaluate the effectiveness of small interfering...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nerve injury and regeneration
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25687501
DOI: 10.2174/156652321405140926160602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau Silencing by siRNA in the P301S Mouse Model of TauopathyPMID 25687501Read ↗

Evaluating the efficacy of commercially available antisense oligonucleotides to reduce mouse and human tau <i>in vivo</i>Semantic proximity Read ↗

Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for TauopathiesSemantic proximity Read ↗

Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathySemantic proximity Read ↗

Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice.Semantic proximity Read ↗

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.Semantic proximity Read ↗

Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.Semantic proximity Read ↗

AAV delivery of artificial miRNA targeting MAPT for the reduction of tau pathology in Alzheimer’s diseaseSemantic proximity Read ↗

Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.Semantic proximity Read ↗

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegenerationSemantic proximity Read ↗

Persistent repression of tau in the brain using engineered zinc finger protein transcription factorsSemantic proximity Read ↗

Transduced wild-type but not P301S mutated human tau shows hyperphosphorylation in transgenic mice overexpressing A30P mutated human alpha-synuclein.Semantic proximity Read ↗

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.