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Article

Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.

ACS chemical neuroscience - 7 Jun 2023

Pathak Pragya, Alexander Krista K, Helton Leah G, Kentros Michalis, LeClair Timothy J, Zhang Xiaojuan, Ho Franz Y, Moore Timothy T, Hall Scotty, Guaitoli Giambattista, Gloeckner Christian Johannes, Kortholt Arjan, Rideout Hardy, Kennedy Eileen J

Abstract excerpt

Missense mutations along the leucine-rich repeat kinase 2 (LRRK2) protein are a major contributor to Parkinson's Disease (PD), the second most commonly occurring neurodegenerative disorder worldwide. We recently reported the development of allosteric constrained peptide inhibitors that target and downregulate LRRK2 activity through disruption of LRRK2 dimerization. In this study, we designed doubly constrained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37200505
DOI: 10.1021/acschemneuro.3c00259
PMCID: PMC10251477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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