The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants.

doi:10.1017/S0033291724000011

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Article

The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants.

Psychological medicine - 1 Jun 2024

Toro Veronica Debora, Antonucci Linda A, Quarto Tiziana, Passiatore Roberta, Fazio Leonardo, Ursini Gianluca, Chen Qiang, Masellis Rita, Torretta Silvia, Sportelli Leonardo, Kikidis Gianluca Christos, Massari Francesco, D'Ambrosio Enrico, Rampino Antonio, Pergola Giulio, Weinberger Daniel R, Bertolino Alessandro, Blasi Giuseppe

Abstract excerpt

BACKGROUND: Previous evidence suggests that early life complications (ELCs) interact with polygenic risk for schizophrenia (SCZ) in increasing risk for the disease. However, no studies have investigated this interaction on neurobiological phenotypes. Among those, anomalous emotion-related brain activity has been reported in SCZ, even if evidence of its link with SCZ-related genetic risk is not solid. Indeed, it...

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PMID: 38305128
DOI: 10.1017/S0033291724000011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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