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The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age.

Psychological medicine - 1 Oct 2018

Riglin Lucy, Collishaw Stephan, Richards Alexander, Thapar Ajay K, Rice Frances, Maughan Barbara, O'Donovan Michael C, Thapar Anita

Abstract excerpt

BACKGROUND: Previous studies find that both schizophrenia and mood disorder risk alleles contribute to adult depression and anxiety. Emotional problems (depression or anxiety) begin in childhood and show strong continuities into adult life; this suggests that symptoms are the manifestation of the same underlying liability across different ages. However, other findings suggest that there are developmental...

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Affective Symptoms
Child
Depressive Disorder, Major
Genome-Wide Association Study
Risk Assessment

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PMID: 29239291
DOI: 10.1017/S0033291717003634

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