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Article

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity.

Human genomics - 1 Feb 2024

Kiiski Johanna I, Neuvonen Mikko, Kurkela Mika, Hirvensalo Päivi, Hämäläinen Kreetta, Tarkiainen E Katriina, Sistonen Johanna, Korhonen Mari, Khan Sofia, Orpana Arto, Filppula Anne M, Lehtonen Marko, Niemi Mikko

Abstract excerpt

BACKGROUND: Individual assessment of CYP enzyme activities can be challenging. Recently, the potato alkaloid solanidine was suggested as a biomarker for CYP2D6 activity. Here, we aimed to characterize the sensitivity and specificity of solanidine as a CYP2D6 biomarker among Finnish volunteers with known CYP2D6 genotypes. RESULTS: Using non-targeted metabolomics analysis, we identified 9152 metabolite features in...

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Identifiers

PMID: 38303026
DOI: 10.1186/s40246-024-00579-8
PMCID: PMC10835938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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