Article
Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
Clinical and translational science - 1 Feb 2024
Smith Robert Løvsletten, Wollmann Birgit M, Størset Elisabet, Lenk Hasan Çağın, O'Connell Kevin S, Kristiansen Marianne Kringen, Ingelman-Sundberg Magnus, Molden Espen
Abstract excerpt
Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%-25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recently described that nuclear factor 1B (NFIB) regulates hepatic CYP2D6 expression with the minor allele of NFIB rs28379954 T>C significantly increasing CYP2D6-mediated risperidone...
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