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Article

Nutrimetric Validation of Solanidine as Dietary-Derived CYP2D6 Activity Marker In Vivo.

Clinical pharmacology and therapeutics - 1 Feb 2024

Müller Julian Peter, Sarömba Jens, Ziegler Patrick, Tremmel Roman, Rengelshausen Jens, Schaeffeler Elke, Just Katja S, Schwab Matthias, Kraus Thomas, Stingl Julia C

Abstract excerpt

CYP2D6 is involved in the metabolism of many drugs. Its activity is affected by pharmacogenetic variability leading to highly polymorphic phenotypes between individuals, affecting safety and efficacy of drugs. Recently, solanidine, a steroidal alkaloid from potatoes, and its metabolites, has been identified as a dietary-derived activity marker for CYP2D6. The intraday variability in plasma within individuals has...

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PMID: 37971251
DOI: 10.1002/cpt.3106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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