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Article

Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity.

British journal of pharmacology - 1 Dec 2021

Magliocco Gaëlle, Desmeules Jules, Matthey Alain, Quirós-Guerrero Luis M, Bararpour Nasim, Joye Timothée, Marcourt Laurence, Queiroz Emerson F, Wolfender Jean-Luc, Gloor Yvonne, Thomas Aurélien, Daali Youssef

Abstract excerpt

BACKGROUND AND PURPOSE: Individualized assessment of cytochrome P450 2D6 (CYP2D6) activity is usually performed through phenotyping following administration of a probe drug to measure the enzyme's activity. To avoid any iatrogenic harm (allergic drug reaction, dosing error) related to the probe drug, the development of non-burdensome tools for real-time phenotyping of CYP2D6 could significantly contribute to...

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Identifiers

PMID: 34363609
DOI: 10.1111/bph.15651
PMCID: PMC9290485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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