Article

Solanidine analysis during therapeutic drug monitoring revealed rare CYP2D6 poor metabolizer genotype: a case report

2025-04-16

Abstract excerpt

CYP2D6 catalyses the metabolism of around 25% of all clinically used drugs. In Caucasians, 5-10% are homozygous carriers of variant alleles encoding no CYP2D6 enzyme activity and classified as poor metabolizers (PMs). Increased risk of supra-therapeutic concentrations and adverse effects of CYP2D6 substrates have been reported in PMs during standard recommended dosing. Recently, semi-quantitative measurements of t...

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Literature Corpus work: c764485d-5284-57ab-9e08-9d7b4a435499
DOI: 10.22541/au.174479429.94335461/v1

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