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Article

Liquid Chromatography-Tandem Mass Spectrometry Quantification of Diet-Derived CYP2D6 Biomarkers for Clinical Phenotyping in Japanese Subjects.

Clinical and translational science - 1 Aug 2026

Kumondai Masaki, Hayashi Nagomi, Matsumoto Yotaro, Ebata Akiko, Sato Miku, Harada-Shoji Narumi, Tada Hiroshi, Miyashita Minoru, Ishida Takanori, Maekawa Masamitsu, Tomioka Yoshihisa, Mano Nariyasu

Abstract excerpt

The enzymatic activity of cytochrome P450 2D6 (CYP2D6) exhibits substantial interindividual variation, which influences drug efficacy and the risk of adverse drug reactions to various therapeutics. While current protocols for CYP2D6 genotyping or CYP2D6 phenotyping provide useful information, less invasive and simpler tools are desirable for evaluating interindividual functional variety. Recently, solanidine...

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PMID: 42473799
DOI: 10.1111/cts.70668
PMCID: PMC13382532

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