Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.

Neurochemical research - 1 Dec 2017

Ur Rasheed Mohd Sami, Mishra Abhishek Kumar, Singh Mahendra Pratap

Abstract excerpt

Cytochrome P450 (CYP) 2D6 is one of the most highly active, oxidative and polymorphic enzymes known to metabolize Parkinsonian toxins and clinically established anti-Parkinson's disease (PD) drugs. Albeit CYP2D6 gene is not present in rodents, its orthologs perform almost the similar function with imprecise substrate and inhibitor specificity. CYP2D6 expression and catalytic activity are found to be regulated at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2D6
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Parkinson Disease

Share to Pharmacogenetics and Drug Metabolism

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 28871472
DOI: 10.1007/s11064-017-2384-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.PMID 28871472Read ↗

CYP2D6 phenotypes and Parkinson's disease risk: a meta-analysis.Semantic proximity Read ↗

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.Semantic proximity Read ↗

Roles of gender, age at onset and environmental risk in the frequency of CYP2D6-deficient alleles in patients with Parkinson's disease.Semantic proximity Read ↗

P450 enzymes and Parkinson's disease: the story so far.Semantic proximity Read ↗

CYP2D6 pharmacogenomicsSemantic proximity Read ↗

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance.Semantic proximity Read ↗

CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.Semantic proximity Read ↗

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.Semantic proximity Read ↗

CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials.Semantic proximity Read ↗

Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6.Semantic proximity Read ↗

CYP450, genetics and Parkinson's disease: gene x environment interactions hold the key.Semantic proximity Read ↗

CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.