Article
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Cardiovascular research - 2 Jul 2024
Ravindran Aarthi, Holappa Lari, Niskanen Henri, Skovorodkin Ilya, Kaisto Susanna, Beter Mustafa, Kiema Miika, Selvarajan Ilakya, Nurminen Valtteri, Aavik Einari, Aherrahrou Rédouane, Pasonen-Seppänen Sanna, Fortino Vittorio, Laakkonen Johanna P, Ylä-Herttuala Seppo, Vainio Seppo, Örd Tiit, Kaikkonen Minna U
Abstract excerpt
AIMS: Vascular smooth muscle cells (SMCs) and their derivatives are key contributors to the development of atherosclerosis. However, studying changes in SMC gene expression in heterogeneous vascular tissues is challenging due to the technical limitations and high cost associated with current approaches. In this paper, we apply translating ribosome affinity purification sequencing to profile SMC-specific gene...
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