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Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

8 Feb 2024

Abstract excerpt

BACKGROUND: Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular disease, the leading cause of mortality and morbidity worldwide. In response to microenvironment alterations, SMCs dedifferentiate from a contractile to a synthetic phenotype characterized by an increased proliferation, migration, production of ECM (extracellular matrix) components,...

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PMID: 38328934
DOI: 10.1161/atvbaha.123.320274

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