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Article

Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance.

Thorax - 14 Jun 2024

Danchuk Sarah N, Solomon Ori E, Kohl Thomas Andreas, Dreyer Viola, Barilar Ivan, Utpatel Christian, Niemann Stefan, Soolingen Dick van, Anthony Richard, van Ingen Jakko, Michael Joy S, Behr Marcel A

Abstract excerpt

OBJECTIVES: Heteroresistant infections are defined as infections in which a mixture of drug-resistant and drug-susceptible populations are present. In Mycobacterium tuberculosis (M. tb), heteroresistance poses a challenge in diagnosis and has been linked with poor treatment outcomes. We compared the analytical sensitivity of molecular methods, such as GeneXpert and whole genome sequencing (WGS) in detecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38286614
DOI: 10.1136/thorax-2023-220202
PMCID: PMC11187393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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