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Highly Sensitive Detection of Isoniazid Heteroresistance in Mycobacterium Tuberculosis by Droplet Digital PCR

1 Oct 2022

Abstract excerpt

Purpose: The drug resistance of Mycobacterium tuberculosis constitutes a major public health threat. Existing approaches make it challenging to detect low levels of drug-resistant TB, also known as heteroresistance (HR), in a population. The recently found droplet digital PCR (ddPCR) is a sensitive method for determining the precise amount of nucleic acid in a sample. We used ddPCR to test the Mycobacterium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36329987
DOI: 10.2147/idr.s381097

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