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Article

Unveiling the complexity of rifampicin drug susceptibility testing in Mycobacterium tuberculosis: comparative analysis with next-generation sequencing.

Journal of medical microbiology - 1 Sept 2024

Qadir Mehmood, Khan Muhammad Tahir, Khan Sajjad Ahmed, Akram Muhammad, Canseco Julio Ortiz, Faryal Rani, Wei Dong Qing, Tahseen Sabira

Abstract excerpt

Introduction. The discordance between phenotypic and molecular methods of rifampicin (RIF) drug susceptibility testing (DST) in Mycobacterium tuberculosis poses a significant challenge, potentially resulting in misdiagnosis and inappropriate treatment.Hypothesis/gap statement. A comparison of RIF phenotypic and molecular methods for DST, including whole genome sequencing (WGS), may provide a better understanding...

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PMID: 39229883
DOI: 10.1099/jmm.0.001884

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