Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution

Abstract excerpt

Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. To clarify the specific contribution of microglia to pain progression, we take advantage of a temporally controlled transgenic approach to transiently deplete microglia. Unexpectedly, we observe complete resolution of pain...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroinflammation and Neurodegeneration Mechanisms
• Share to Neuropeptides and Animal Physiology
• Share to Pain Mechanisms and Treatments