Article

Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolution

2022-12-21

Abstract excerpt

<h4>Summary</h4> Microglia contribute to the initiation of pain, however, a translationally viable approach addressing how or when to modulate these cells remains elusive. We used a targeted, inducible, genetic microglial depletion strategy at both acute and acute-to-chronic transition phases in the clinically-relevant tibial fracture/casting pain model to determine the contribution of microglia to the initiation...

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Literature Corpus work: 6f37c5e6-d557-501f-86fd-651cec80c5e8
DOI: 10.1101/2022.12.20.521295

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