Article

Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic pain

2020-12-10

Abstract excerpt

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it remains unknown whether distinct microglia subpopulations or states contribute to different stages of pain development and maintenance. We show, using single-cell RNA-sequencing, that nerve injury induces the generation of a male-specific inflammatory micro...

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Literature Corpus work: 16eff8cf-21b9-5bfb-90fd-5b104b1ec8ba
DOI: 10.1101/2020.12.09.418541

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Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic painDOI 10.1101/2020.12.09.418541Read

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