Article
The Influence of ESR2 Gene Polymorphisms on Susceptibility to Hepatitis B Virus-Related Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma.
Biochemical genetics - 1 Oct 2024
Jie Zeng, Hongkun Jiang, Shi Yang, Fengxun Yang, Xin Liu, Yijun Meng, Yu Lu
Abstract excerpt
Hepatocellular carcinoma (HCC) represents an estrogen-dependent tumor. The action of estrogen is regulated via estrogen receptor (ER). Polymorphisms in ERα gene, ESR1, are known to be related to HCC susceptibility among people carrying chronic hepatitis B (CHB). But the effect of ERβ on HCC is still largely unclear, and studies about the genetic variability of ESR2 and HCC are rare. For understanding ESR2's...
Topics
- Humans
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Male
- Female
- Hepatitis B, Chronic
- Genetic Predisposition to Disease
- Liver Cirrhosis
- Middle Aged
- Polymorphism, Single Nucleotide