Article
Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population.
BMC medical genetics - 24 Jun 2012
Yan Zehui, Tan Wenting, Dan Yunjie, Zhao Wenli, Deng Chunqing, Wang Yuming, Deng Guohong
Abstract excerpt
BACKGROUND: The sexual dimorphism of hepatitis B virus (HBV) -related liver diseases is related with estrogen and its receptors. Recent reports indicate that abnormal expression of estrogen receptor alpha (ESR1) may be a hallmark for the progression of liver disease and HBV carriers presenting variant ESR1 have an extremely aggressive clinical course. Here we examine whether the ESR1 polymorphisms or its...
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