Article
Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China.
Carcinogenesis - 1 May 2010
Park Sue K, Andreotti Gabriella, Rashid Asif, Chen Jinbo, Rosenberg Philip S, Yu Kai, Olsen Jennifer, Gao Yu-Tang, Deng Jie, Sakoda Lori C, Zhang Mingdong, Shen Ming-Chang, Wang Bing-Sheng, Han Tian-Quan, Zhang Bai-He, Yeager Meredith, Chanock Stephen J, Hsing Ann W
Abstract excerpt
Biliary tract cancer encompasses tumors of the gallbladder, bile duct and ampulla of Vater. Gallbladder cancer is more common in women, whereas bile duct cancer is more common in men, suggesting that sex hormones may play a role in the etiology of these cancers. The intracellular action of estrogens is regulated by the estrogen receptor (ESR); thus, we examined the role of common genetic variants in ESR genes on...
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