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Article

A cis-acting regulatory variation of the estrogen receptor α (ESR1) gene is associated with hepatitis B virus-related liver cirrhosis.

Human mutation - 1 Oct 2011

Yan Zehui, Tan Wenting, Xu Baoyan, Dan Yunjie, Zhao Wenli, Deng Chunqing, Chen Wen, Tan Shun, Mao Qing, Wang Yuming, Deng Guohong

Abstract excerpt

The hepatic fibrogenesis and sexual dimorphism of hepatitis B virus-related liver cirrhosis (HBV-LC) are related to estrogen and its receptors. Abnormal expression of estrogen receptor α (ESR1) is implicated in the development of cirrhosis in both animal models and humans. Here, we examine whether the ESR1 polymorphisms are related to HBV-LC risk among chronic HBV carriers, and we investigate the functional...

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Source

Identifiers

PMID: 21837769
DOI: 10.1002/humu.21544

Genes

ESR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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